About the project
We know the composition of the pentameric tRNA ligase complex, its three-dimensional structure (partially) and the biochemistry of RTCB, its catalytic subunit; however, the function of the other subunits and their isoforms remain unknown. We have also identified Archease, a co-factor that turns the tRNA ligase complex into a multiple turnover enzyme (Popow et al. 2014, Nature). Archease is “unfaithful” to the ligase by binding to another protein… What is the importance of that interaction?
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You will have the opportunity to solve these mysteries – and eventually others! – by mastering molecular biology, biochemistry and structural biology. You will be working in a vibrant and creative lab atmosphere, and will be trained to think critically, and write and communicate your results and ideas in a professional way!
Candidates
Please apply if you love RNA Biology and molecular mechanisms, from atomic detail to physiology. We are looking for bright and energetic students with a passion for science and good organizational skills. Experience at the bench is certainly a plus.
Application and contact
Please contact us until August 31, 2023. Enclose your CV, a short motivation letter and, eventually, a recommendation letter. We will then contact you for an interview. javier.martinez@meduniwien.ac.at
